Monoclonal antibody Sa 3 against HLA class II (DR, DQ and DP) antigens and its application
نویسندگان
چکیده
منابع مشابه
HLA class II antigens (DR, DQ loci) and peripheral arthritis in ankylosing spondylitis.
Fifty one patients with ankylosing spondylitis (AS) were typed for HLA-A, B, C, DR, and DQ antigens. The antigen frequencies were compared with those of a normal population and with a B27 positive control group. All but one of the patients with AS were HLA-B27 positive. A positive linkage disequilibrium between Cw1, Cw2, DR1, and the B27 antigen was observed. Patients with AS showed a significa...
متن کاملHLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM.
The MHC is central to the adaptive immune response. The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, each being highly polymorphic. In contrast to HLA-DR, the intracellular assembly and trafficking of HLA-DP molecules have not been studied extensively. However, different HLA-DP variants can be either protective or risk factors for infectious diseases (e.g. he...
متن کاملAnalysis of MHC class II DP, DQ and DR alleles in Crohn's disease.
BACKGROUND Although inflammation in Crohn's disease is believed to be mediated by activated T cells, genotyping of all MHC class II alleles in white people with this disease has not been reported. AIMS To perform a detailed molecular analysis of HLA DPB, DQB, and DRB genes in white patients with Crohn's disease and controls in order to determine if the inheritance of any class II genes confer...
متن کاملHLA-A, B (Class I) and HLA-DR, DQ (Class II) Antigens in Turkish Patients with Recurrent Aphthous Ulceration and Behçet's Disease
OBJECTIVE The aims of the present study were to typify the human leukocyte antigen system (HLA)-A, B (class I) and HLA-DR, DQ (class II) antigens and to assess the frequency of the presence of these antigens in the Turkish population with recurrent aphthous ulceration (RAU) and Behçet's disease (BD) compared to healthy subjects. SUBJECTS AND METHODS Thirty patients with RAU, 30 with BD, and 1...
متن کاملPattern of expression of HLA-DR and HLA-DQ antigens and mRNA in myeloid differentiation.
We examined the expression of HLA-DR and HLA-DQ antigens and mRNA from myeloid and lymphoid cells obtained from normal volunteers and established cell lines. Cytofluorometric analysis and immunoprecipitation were performed using murine monoclonal antibodies specific for HLA-DR (L-243) and HLA-DQ (Leu 10). The expression of mRNA for HLA-DR and HLA-DQ chains was determined by Northern blot and RN...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 1986
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.9.484